GLP-1 Receptor Agonists for Weight Loss in People without Type …
May 12, 2023 · In an article published in the American Journal of Clinical Nutrition, Liu et al. performed a systematic review with meta-analyses of trials evaluating the effects of GLP-1 RAs on weight loss in people without diabetes.
Emerging Role of GLP-1 Agonists in Obesity: A Comprehensive …
GLP-1 agonists, used to treat type 2 diabetes, have been shown to be effective in promoting weight loss in preclinical and clinical studies. This review summarizes numerous studies conducted on the main drugs in the GLP-1 agonists class, …
Efficacy of GLP-1 Agonists for Weight Loss in Adults Without Diabetes
Jun 16, 2022 · The new indications include weight loss in adults with obesity (body mass index [BMI] ≥30) without diabetes and adults with a BMI ≥27 and 1 weight-related comorbidity (hypertension, type 2 ...
A Balancing Act: GLP-1 Receptor Agonists for Non-Diabetic Obesity
Dec 29, 2020 · GLP-1 agonists are a promising drug class originally developed for the treatment of type 2 diabetes, but recently shown to be effective for weight loss in non-diabetic patients with obesity or overweight BMI when given as adjunctive therapy to diet and exercise. 8 Endogenous glucagon-like peptide-1 (GLP-1) is a peptide secreted from intestinal ...
Efficacy of GLP-1 RA Approved for Weight Management in …
The mean weight loss difference between GLP-1 RAs and placebo as add-on to lifestyle intervention in patients with diabetes was 4% to 6.2% compared to 6.1 to 17.4% in people without diabetes. Semaglutide compared to liraglutide resulted in greater weight loss.
GLP−1 receptor agonists for the treatment of obesity: Role as a ...
Like other GLP-1R agonists, when used alone or treated with non-insulin secretagogues, DUL treatment is associated with weight loss or decreased weight gain . It has a long half-life period and is injected once a week.
The Weight-loss Effect of GLP-1RAs Glucagon-Like Peptide-1 …
The present study provides conclusive evidence for the effect of GLP-1RAs on weight loss in a nonlinear dose-response manner in patients with obesity or overweight without diabetes. In terms of changes in BW, BMI, and WC, there is firm evidence for the overall weight-loss effects of …
GLP-1 RAs efficacious for weight loss in overweight, obesity …
Jan 7, 2025 · For adults with overweight or obesity without diabetes, glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are efficacious for weight loss, according to a review published online Jan. 7 in the ...
Exploring GLP-1 for Weight Loss in Non-Diabetics
Apr 21, 2024 · For non-diabetics, the primary benefit of GLP-1 is its potential to aid in substantial and sustained weight loss. This is particularly valuable for individuals who have struggled with obesity and related health issues despite attempting other weight loss methods.
systematic reviews showed that GLP-1 RAs effectively reduce weight in people living with obesity (but without diabetes), particularly in the initial years of treatment. However, they also reported several associated harm outcomes that could deter the …
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