Targeting to BMP9 to restrain flare-up of fibrodysplasia ossificans ...
Dec 3, 2024 · On a molecular level, FOP is caused by a gain-of-function mutation in the activin A receptor type I (ACVR1, also known as activin-like kinase 2, ALK2), a type I receptor in the bone morphogenetic protein (BMP) pathway (Shore et al, 2006).This mutation involves a substitution of guanine with adenine, resulting in an arginine (R) to histidine (H) change at codon 206 in the intracellular glycine ...
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Adaptation, redundancy or resilience | EMBO reports
Sep 1, 2011 · In order to improve our understanding of complex diseases, we can extend this notion of diverse ecosystems to organisms. Similarly to the disappearance of one species in an ecosystem with abundant biodiversity, the loss of one gene function might not be immediately apparent, because many such changes can be compensated …
A novel LRR receptor-like kinase BRAK reciprocally phosphorylates …
Oct 24, 2024 · Rapid and accurate detection of pathogens or pathogen-associated signals is a prerequisite for initiating plant defense responses. Numerous pattern recognition receptors (PRRs) on plant cell surfaces detect diverse pathogen-derived elicitors (Schwessinger and Ronald, 2012; Ngou et al, 2022).Among them, receptor-like kinases (RLKs) and receptor-like proteins (RLPs) are particularly essential.
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Viral N protein hijacks deaminase-containing RNA granules to …
Nov 20, 2024 · Human deaminases, including the adenosine deaminases acting on RNA (ADARs) and the apolipoprotein-B (ApoB) mRNA editing enzyme, catalytic polypeptide-like proteins (APOBECs), play critical roles in innate antiviral defense (Samuel, 2011; Sheehy et al, 2003; Wang et al, 2020a).ADARs deaminate adenosines in double strand RNAs (dsRNAs), converting them into inosines (A > I conversion) (Roth et al ...
Osmotic signaling releases PP2C-mediated inhibition of
Oct 21, 2024 · To survive under drought and osmotic stress, terrestrial plants have evolved osmoregulatory mechanisms, such as activation of SNF1-related protein kinase 2s (SnRK2s) (Boudsocq et al, 2004; Fujii et al, 2011), accumulation of abscisic acid (ABA), and activation of ABA signaling (Zhu, 2016).Since osmoregulation often antagonizes plant growth and development (Zhang et al, 2020), osmotic signaling ...
Deciphering the molecular logic of WOX5 function in the root …
Nov 18, 2024 · The stem cells that give rise to the different files of cell types in the root are localized around the QC cells (Dolan et al, 1993; Pardal and Heidstra, 2021; Rahni and Birnbaum, 2019): The proximal stem cells give rise to the stele, endodermis, and cortex, the lateral ones to the epidermis and the lateral root cap, and the distal stem cells to the gravity-sensing columella (Dolan et al, 1993).
ZBTB48 is a priming factor regulating B-cell-specific CIITA expression
Nov 19, 2024 · CIITA transcription itself is controlled by a 14 kb multi-promoter regulatory region, containing three independent promoter elements in humans, pI, pIII, and pIV, which are expressed in a tissue-specific manner (Muhlethaler‐Mottet et al, 1997). pI is expressed in dendritic cells and macrophages (Muhlethaler‐Mottet et al, 1997; Pai et al, 2002), while pIII is responsible for constitutive ...
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5 days ago · This cover highlights the article Deciphering the molecular logic of WOX5 function in the root stem cell organizer by Ning Zhang, Pamela Bitterli, Thomas Laux and colleagues. The image highlights the expression (green color) of WOX5 in the root stem cell organizer, the quiescent center.