Modern clinical genetics in cardiology | Heart
Jan 11, 2025 · Advances in molecular genetics during the past decades led to seminal discoveries in the genetic basis of cardiovascular diseases, resulting in a new understanding of their pathogenesis, determinants of natural history and more recently paved the way for innovative therapies. A significant gap, however, exists between the rapidly increasing knowledge, especially of cardiovascular Mendelian ...
Coronary microvascular function and atherosclerotic plaque …
Background The relationship between atherosclerosis and endotypes of myocardial ischaemia with no obstructive coronary artery disease (INOCA) is unclear. We investigated potential associations between cumulative atherosclerotic plaque burden quantified using the Gensini score, novel invasive indices of coronary microvascular function (microvascular resistance reserve (MRR); resistive reserve ...
Bradyarrhythmias in patients with atrial fibrillation | Heart
The increasing burden of atrial fibrillation (AF) and significant morbidity/mortality associated with this arrhythmia encourage screening it in clinical practice, as recommended in current guidelines. It means opportunistic screening (in patients over 65 years) or systematic screening (in people above 75 years) by using clinical examination, followed by an ECG, 24-hour ECG monitoring or ...
How the brain impacts the heart: lessons from ischaemic stroke …
Cardiovascular alterations are common in patients who had ischaemic stroke, haemorrhagic stroke and other acute brain disorders such as seizures. These cardiac complications are important drivers of morbidity and mortality and comprise blood-based detection of cardiomyocyte damage, ECG changes, heart failure and arrhythmia. Recently, the concept of a distinct ‘stroke-heart syndrome’ has ...
International collaborative action to advance women’s ... - Heart
Established in 2018, the Global Cardiovascular Research Funders Forum (GCRFF) unites 12 leading charitable and public research funding organisations across nine countries. Our mission is to enhance global cardiovascular health through advancing and supporting international collaboration in research on heart and blood vessel diseases. The forum has been created to facilitate the exchange and ...
Relative survival after aortic valve surgery in patients with bicuspid ...
Objectives The objective of this cohort study was to analyse long-term relative survival in patients with bicuspid aortic valve (BAV) who underwent aortic valve surgery. Methods We studied 865 patients with BAVs who participated in three prospective cohort studies of elective, open-heart, aortic valve surgery at the Karolinska University Hospital, Stockholm, Sweden, between …
AF and COVID-19: a potentially lethal combination - Heart
Since the outbreak of the pandemic until early 2022, SARS-CoV-2 infection (COVID-19) has affected more than 410 million individuals worldwide, and of those almost 5.9 million people have died. COVID-19 mortality is strongly associated with advanced age, comorbidities, thromboembolism and vaccination status (www.COVID-19.who.int). Atrial fibrillation (AF) is the most common sustained arrhythmia ...
Aortic sclerosis: not an innocent murmur but a marker of ... - Heart
The detection of an ejection systolic murmur in the aortic valve region often corresponds to a diagnosis of aortic sclerosis or minor disruption of the aortic valve with associated turbulence but minimal obstruction. Aortic sclerosis has two important clinical implications. Firstly, aortic sclerosis is an antecedent to clinically significant aortic valve obstruction and, secondly, it acts as a ...
Functional assessment of coronary artery disease in patients with ...
Dec 12, 2024 · A significant proportion of patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve implantation (TAVI) have concomitant coronary artery disease (CAD). The best way to treat these patients is contentious. Conventional assessments of ischaemia such as fractional flow reserve (FFR) and instantaneous wave-free ratio are not validated in the context of severe AS despite ...
Homepage | Heart
Jan 23, 2011 · Heart is an international peer reviewed journal that keeps cardiologists up to date with important research advances in cardiovascular disease. New scientific developments are highlighted in editorials and put in context with concise review articles. There is one free Editor’s Choice article in each issue, with open access options available to authors for all articles. Education in Heart ...