2 days ago · In a small clinical trial of nine patients with stage III and IV kidney cancer, a personalized anti-tumor vaccine generated robust immune response, according to findings of a new study led by HMS researchers at Dana-Farber Cancer Institute.The patients had a form of kidney cancer called clear cell renal cell carcinoma and were deemed at high risk for …

Dana-Farber Cancer Institute researchers report that all nine patients in a clinical trial being treated for stage III or IV clear cell renal cell carcinoma (a form of kidney cancer), generated a successful anti-cancer immune response after initiation of a personalized cancer vaccine.

1 day ago · THURSDAY, Feb. 6, 2025 (HealthDay News) -- A small, early trial of a vaccine that mobilizes the immune system to battle advanced kidney cancers appears successful, researchers report. The "personalized cancer vaccines" (PCVs) used by the nine patients in the trial were targeted to genes specific to their tumors, explained a team led by Dr ...

2 days ago · Nine patients with advanced kidney cancer who received an experimental vaccine tailored to their tumors’ specific mutations mounted an immune response to their disease and remained cancer-free ...

2 days ago · All nine patients with advanced kidney cancer in an early-phase trial of a personalized therapeutic vaccine had successful anti-cancer immune responses and remained cancer-free approximately three years after treatment. A therapeutic vaccine is used after disease sets in, aiming to induce immunity to alter the course of disease.

1 day ago · Dr David Braun, physician-scientist at Yale Cancer Center and first author of the study, said: “This approach is truly distinct from vaccine attempts in kidney cancer. “We pick targets that are unique to the cancer and different from any normal part of the body, so the immune system can be effectively ‘steered’ towards the cancer in a ...

2 days ago · But kidney cancer is a disease with fewer mutations, and therefore fewer targets to manufacture the vaccine. It was important for the investigators to learn as much as possible from this early ...