NFL betting returned over the weekend with preseason football games. In the first full week of action, some teams opted to rest their starters, while others played a few series and in some instances even more than that.

Before the first whistle of the 2025 college football season blows and play begins, the betting market is already moving. Week 1 lines are live at ESPN BET with season win totals and futures shaping up. Each team in the preseason AP top 25 poll has a story, whether it's a rebuild, a reload or a revenge tour.

Two of the best bets to consider across Saturday's NFL preseason matchups are the Giants to put up some points vs. the Bills and the Cowboys to beat the Rams.