The Israeli army said on Saturday it had called up reservists to bolster its forces along the borders with Lebanon and Syria, amid fears of a regional escalation as tensions with Iran reach unprecedented levels.

Iran launched a second round of missiles against Israel late Saturday as Israel’s military kept up attacks in Iran following earlier strikes that targeted nuclear and military sites. They also killed key leaders in the country’s governing theocracy.

Iran’s “Axis of Resistance,” the network of militias it has fostered in the Middle East to help it fight Israel, has become seriously degraded, experts say.

Lebanon will aim to keep its airspace open, a minister said on Saturday, hours after officials said the airspace would be shut down in the evening amid Iran-Israel conflict.

Israel strikes Iran after neutralizing Hezbollah as Tehran’s response falters, exposing deep regional shifts and vulnerabilities.

Launching weapons from within their territory forces adversaries to look not only outward but also inside for threats, one expert said.

The attack was a stiff challenge for Israel’s air-defense system, which has intercepted projectiles fired from Gaza, Lebanon, Syria, Iraq, Yemen and Iran since the start of the war Oct. 7, 2023. They have ranged from short-range rockets to medium-range missiles to attack drones to ballistic missiles like those fired Friday night.

Israel warns "Tehran will burn" if Iran continues firing missiles, while state media say 60 people have been killed in a strike on Iran's capital.