eLife3d
Ezh2 Delays Activation of Differentiation Genes During Normal Cerebellar Granule Neuron Development and in Medulloblastoma
Using an unbiased approach, this important study discovered a role of Ezh2 in the differentiation of granule neuron precursors, the cell of origin for Shh group of medulloblastoma. Furthermore, the ...
AZoLifeSciences on MSN9d
Cryo-EM Reveals 3D Structure of Nipah Virus RNA Polymerase
The replication of the Nipah virus's genetic material in infected cells has been demonstrated for the first time by ...
Informationsdienst Wissenschaft11d
Molecular 3D structure of viral "copying machine" deciphered
Dr. Hauke Hillen was able to visualize the three-dimensional structure of the viral "copying machine". These findings could contribute to the future development of antiviral drugs for the treatment of ...
C&EN22d
Targeting Bacterial RNA Polymerase: Harnessing Simulations and Machine Learning to Design Inhibitors for Drug-Resistant Pathogens
The increase in antimicrobial resistance presents a major challenge in treating bacterial infections, underscoring the need for innovative drug discovery approaches and novel inhibitors. Bacterial RNA ...
The EMBO Journal23d
Cytosolic CRISPR RNAs for efficient application of RNA-targeting CRISPR-Cas systems
In particular, RNA-targeting CRISPR-Cas13 proteins are promising single-effector systems to regulate target mRNAs without altering genomic DNA, yet the current Cas13 systems are restrained by ...
Pharmabiz28d
Acurx Pharmaceuticals’ DNA Polymerase IIIC Inhibitors receives Japanese patent
This patent relates to DNA Polymerase IIIC Inhibitors, including compositions-of-matter, surface coatings and pharmaceutical compositions for use in methods of treating Gram-positive bacterial ...
Scientific Research Publishing29d
Osawa, T., Aoki, M., Ehara, H. and Sekine, S. (2023) Structures of Dengue Virus RNA Replicase Complexes. Molecular Cell, 83, 2781-2791.E4.
The RNA-dependent RNA polymerase (RdRp) domain of the NS5 protein within the NS5-NS3 complex was selected as the molecular docking template. Molecular docking simulations were conducted using ...
Yahoo Finance1mon
JPO Grants Acurx Pharmaceuticals Patent in Japan for DNA Polymerase IIIC Inhibitors
This patent relates to DNA Polymerase IIIC Inhibitors, including compositions-of-matter, surface coatings and pharmaceutical compositions for use in methods of treating Gram-positive bacterial ...
technologynetworks1mon
RNA Inhibitor Reduces “Bad Cholesterol” in Patients With Cardiovascular Disease
The RNA inhibitor olpasiran significantly reduces a type of “bad cholesterol” that’s associated with a high risk of cardiovascular events, according to results from an analysis by a Mount Sinai ...