Laiho holds patents on RNA polymerase 1 inhibitors, which are managed by The Johns Hopkins University in accordance with its conflict-of-interest policies.

Glucose levels influence physiology and adaptation rates under replication stress, yet core adaptive mutations remain ...

The tumor suppressor p53 is a transcription factor that controls the expression of hundreds of genes. Emerging evidence suggests that the p53-induced RNA-binding protein ZMAT3 is a key splicing ...

It follows a previous report showing that the Werner syndrome protein WRN and its interacting protein WRNIP1 are indispensable for translesion DNA synthesis (TLS) by Y-family DNA polymerases (Pols).

Background Chronic inflammation and elevated reactive oxygen species are key contributors to hepatocellular carcinoma (HCC) ...

Bill Gates warns that continued U.S. cuts to global health aid could result in 8 million additional child deaths by 2040, urging Congress to reverse course and restore funding to critical programs ...

As of June 18, 2025, RNA has a market capitalization of $3.539 billion, reflecting investor confidence in its pipeline and technology platform. The company’s financial position appears solid, with ...

The limited therapeutic options against the influenza virus (flu) and increasing challenges in drug resistance make the search for next-generation agents imperative. In this context, heterotrimeric ...

Starcevic, D., Dalal, S. and Sweasy, J.B. (2004) Is There a Link between DNA Polymerase Beta and Cancer Cell Cycle, 3, 996-999.