Colorectal cancer (CRC) is the third most common malignancy and the second leading cause of cancer-related deaths worldwide.

Ten projects at Queen’s are receiving support from the Canadian Institutes of Health Research to advance research that will have a high impact on health care knowledge and delivery.

A new review published in Genes & Diseases highlights macrophage-targeted therapy as a promising frontier in cardiac regeneration and myocardial repair.

Cardiovascular disease (CVD) is the leading cause of death and disease burden worldwide. Macrophages are important components of the internal immune cells, which profoundly affects the internal ...

When we think of type 2 diabetes, images of heart problems or kidney damage often come to mind. But lurking quietly behind these well-known complications is another serious threat—bone disease.

A pioneering study offers unprecedented insights into the bone immune microenvironment of type 2 diabetic mice, uncovering a unique genetic profile ...

1Guangdong Provincial Key Laboratory of Pharmaceutical Functional Genes, MOE Key Laboratory of Gene Function and Regulation, School of Life Sciences, Sun Yat-sen University, Guangzhou, P. R. China.

Triggering receptor expressed on myeloid cells 2 (TREM-2) modulates TLR4-mediated inflammation in bone marrow (BM)-derived macrophages but its function in liver injury is unknown. Here we hypothesised ...

joint injury causes massive diversification and influx of immune subsets. Macrophages exhibited the greatest expansion, and our single-cell transcriptomic analyses identified a resident macrophage ...

When exposed to various stimuli, monocytes/macrophages are recruited to and retained within the local tissue microenvironment, where they can activate and display either proinflammatory or ...