The complement system is a part of the immune system that enhances (complements) the ability of antibodies and phagocytic cells to clear microbes and damaged cells from an organism, ... Complement ...

The ascidian complement system — which consists of MBL-like lectin, ficolins, two MASPs, C3 and C3 receptor — functions in an opsonic manner, and it constitutes a primordial complement system ...

The drug targets C1s, but it selectively blocks just one of three downstream pathways in the complement cascade. The classical pathway is interrupted, while the alternative and lectin pathways ...

MASP-1 and the lectin pathway Behind the discovery of the central role of MASP-1 in the complement system is, apart from Soeren Egedal Degn, also the Aarhus professors Jens Chr. Jensenius and ...

Omeros’ OMS721 is a human monoclonal antibody that inhibits MASP-2, which is the effector enzyme of the lectin pathway of the complement system. Omeros controls the worldwide rights to MASP-2 ...

Complement activates three pathways, despite the lack of specificity of the components of the acquired immune system: the lectin pathway, the classical pathway, and the alternative activation ...

It also contains a stem that activates a defense mechanism called the lectin complement system (Figure 3). Mannose-binding lectin and the lectin complement pathway evolved well before antibodies ...

Narsoplimab is the company’s lead human monoclonal antibody targeting mannan-binding lectin-associated serine protease-2 (MASP-2), the effector enzyme of the lectin pathway of the complement ...

Each pathway triggers a series of reactions leading to the creation of C3 convertase, known as the ‘early’ events of complement activation. C3 convertase is bound covalently to the pathogen.