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Remarkably, activation-associated displacement of ATP from the nucleotide-binding pocket of a PKCɛ mutant that weakly binds ATPcoincided with rapid dephosphorylation of all three PKCɛ priming sites.
ATP and ADP signaling is mainly proinflammatory, ... Examples of nucleotide-receptor signaling in inflammatory conditions include P2Y6- or P2X7-receptor signaling, ...
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AZoLifeSciences on MSNHow Does DNA Unwind? Study Explores Helicase Mechanisms In DNA ReplicationThis study reveals how SV40 helicase unwinds DNA, highlighting ATP hydrolysis's role in translocation and offering insights ...
Mutations in the gene that encodes a protein called adenine nucleotide translocator ... generate most of the ATP needed to fuel body's cells and play an important role in high-energy demanding ...
Researchers aim to apply these findings to produce more complex ATP- and ADP-coupled biomolecules to investigate their role and significance in cell function. “Our ultimate goal is to elucidate their ...
In general, ATP concentrations must be maintained above 1 mM, with a high ATP/ADP.Pi ratio, in order to sustain the energy needed for RNA and nucleotide biosynthesis.
When ATP or ADP were added, this further increased gripping and friction, indicating two mechanisms of motor-DNA interaction -- nucleotide-dependent and nucleotide-independent.
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