The Cubs swept the White Sox in the first series of the 2025 Crosstown Classic by a combined score of 26-8. Here are three takeaways.

Preview the May 17 matchup between the Chicago Cubs and Chicago White Sox with odds over/under, game spread, betting lines and more.

Vargas, who hit a solo home run in the fourth, didn’t take kindly to the pitch and let Keller know without saying a word. He glared at Keller as umpire Jeremie Rehak walked between them.

Colin Rea gets the start for the Chicago Cubs on Sunday against Miguel Vargas and the Chicago White Sox. First pitch is at 2:20 p.m. ET at Wrigley Field. The Cubs have the 16th-ranked team ERA among all league pitching staffs (3.98). The White Sox's 36 home runs rank 27th in MLB this season.

The Chicago White Sox have placed left-hander Tyler Gilbert on the 15-day injured list with a sprained MCL in his left knee.

Cannon had retired 13 consecutive batters before his defense let him down. The Cubs scored three runs in the inning en route to a 6-2 victory.