Football matchup of the 2024 regular season is a rematch of the dramatic NFC Championship Game that sent the San Francisco 49ers to the Super Bowl and ended the Detroit Lions’ season. The two teams are coming into Week 17 in different places than they were at this time last year.

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The Lions travel to Santa Clara to battle the 49ers on Monday Night Football. The 49ers-Lions game starts at 8:15 p.m. ET on ESPN, ESPN+, and ABC. Nope. But Peyton and Eli will return for Wild Card Weekend on January 13, 2025.