The University of Hong Kong has patented RNA polymerase β subunit/RNA polymerase sigma factor RpoD (bacterial) interaction inhibitors reported to be useful for the treatment of gram-positive bacterial ...

Corp. and St. Jude Children’s Research Hospital Inc. have jointly patented compounds acting as caseinolytic protease P (ClpP) (bacterial) activators and RNA polymerase (bacterial) inhibitors and their ...

Using an unbiased approach, this important study discovered a role of Ezh2 in the differentiation of granule neuron precursors, the cell of origin for Shh group of medulloblastoma. Furthermore, the ...

PA protein is one subunit of the polymerase of influenza viruses and plays a critical ... releasing the viral genome into the cytoplasm. RNA Release and Transcription: The influenza virus RNA genome ...

The RNA polymerase is responsible for the replication of viral genetic material and the activation of viral genes, and is essential for the replication of the virus in cells. It is therefore a ...

In December 2024, Atea announced that its Phase 2 study evaluating the regimen of bemnifosbuvir, a nucleotide analog polymerase inhibitor, and ruzasvir, an NS5A inhibitor, for treatment of ...

TABLE 1. Functional roles of m 6 A regulators in RNA metabolism. It has been confirmed that for most cells in reproductive and other systems, the precise regulation of gene expression occurs at the ...

Poly adenosine diphosphate-ribose polymerase inhibitors, an important class of anticancer drugs, employ synthetic lethality strategy and are particularly effective against cancers with genetic ...

A novel, allosteric and highly potent USP1 inhibitor, LAE120 exhibits robust tumor inhibitory activity across various xenograft models Significantly accelerated the progress of drug discovery ...