BioWorld1d
Arietis, St. Jude Children’s Research Hospital report dual action antibiotics in patent
Corp. and St. Jude Children’s Research Hospital Inc. have jointly patented compounds acting as caseinolytic protease P (ClpP) (bacterial) activators and RNA polymerase (bacterial) inhibitors and their ...
eLife10d
Ezh2 Delays Activation of Differentiation Genes During Normal Cerebellar Granule Neuron Development and in Medulloblastoma
Using an unbiased approach, this important study discovered a role of Ezh2 in the differentiation of granule neuron precursors, the cell of origin for Shh group of medulloblastoma. Furthermore, the ...
AZoLifeSciences on MSN17d
Cryo-EM Reveals 3D Structure of Nipah Virus RNA Polymerase
The replication of the Nipah virus's genetic material in infected cells has been demonstrated for the first time by researchers from the Max Planck Institute (MPI) for Multidisciplinary Sciences and ...
Informationsdienst Wissenschaft18d
Molecular 3D structure of viral "copying machine" deciphered
Dr. Hauke Hillen was able to visualize the three-dimensional structure of the viral "copying machine". These findings could contribute to the future development of antiviral drugs for the treatment of ...
C&EN29d
Targeting Bacterial RNA Polymerase: Harnessing Simulations and Machine Learning to Design Inhibitors for Drug-Resistant Pathogens
The increase in antimicrobial resistance presents a major challenge in treating bacterial infections, underscoring the need for innovative drug discovery approaches and novel inhibitors. Bacterial RNA ...