C&EN1mon
Targeting Bacterial RNA Polymerase: Harnessing Simulations and Machine Learning to Design Inhibitors for Drug-Resistant Pathogens
Bacterial RNA polymerase (RNAP) has emerged as a crucial target for antibiotic development due to its essential role in transcription. RNAP is a molecular motor, and its function relies heavily on the ...
Nature1y
Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site
In (+)-stranded RNA viruses, RNA is the sole genetic material. Because infected host cells ordinarily lack RNA-dependent RNA polymerase (RdRp ... infects nearly 3% of the world's population.
Frontiers1y
Improved single-cell genome amplification by a high-efficiency phi29 DNA polymerase
2016). Consequently, the wide-type phi29 DNA polymerase could only complete MDA reaction with trace extracted genomic DNA as template, which is not suitable for single-cell analysis. 3.2 Introduction ...
Frontiers3y
Molecular Dissection of the Primase and Polymerase Activities of Deep-Sea Phage NrS-1 Primase-Polymerase
PrimPols are a class of primases that belong to the archaeo-eukaryotic primase (AEP) superfamily but have both primase and DNA polymerase activities. Replicative polymerase from NrS-1 phage (NrSPol) ...
eLife9y
Methylation of RNA polymerase II non-consensus Lysine residues marks early transcription in mammalian cells
These messenger RNAs are then used as templates for protein production. In animals, plants and other eukaryotic organisms, an enzyme called RNA polymerase II is responsible for making messenger RNA ...
eLife9y
RNA polymerase errors cause splicing defects and can be regulated by differential expression of RNA polymerase subunits
Errors during transcription may play an important role in determining cellular phenotypes: the RNA polymerase error rate is >4 orders of magnitude higher than that of ...