FAU neuroscientists have identified that the receptor IL-1R1 plays a critical role in enabling neurons to directly communicate with the immune system. The new study provides the most detailed mapping ...

The interleukin 1 receptor antagonist (IL1Ra) family of molecules now includes one secreted isoform (sIL1Ra) and three intracellular isoforms (icIL1Ra1, 2, and 3). Extensive evidence indicates that ...

C M Gavin, E M Barberan, A Parry-Jones, J Selvarajah, J Staniland, C Sherrington, D G Hughes, IW Turnbull, G Morris, S Scarth, K Illingworth. Competing interests: N J Rothwell holds a patent for ...

Objectives Interleukin-1 receptor-associated kinase (IRAK)-M suppresses Toll-like receptor (TLR)-mediated activation of innate immunity during infection. A similar role was hypothesised for IRAK-M in ...

we identified that interleukin-1β (IL-1β), a key mediator of inflammation, inhibits syncytia formation mediated by various SARS-CoV-2 strains. Mechanistically, IL-1β activates RhoA/ROCK signaling ...

Cellular events such as adhesion, migration, and invasion of leukocytes into vascular cells occur concomitantly with the production of proinflammatory cytokines such as interleukin-6 ... the RAS on ...

Cellular events such as adhesion, migration, and invasion of leukocytes into vascular cells occur concomitantly with the production of proinflammatory cytokines such as interleukin-6 ... the RAS on ...