USC Dornsife researchers found that mifepristone, a drug already used for medical treatments, may extend lifespan by enhancing mitophagy, similar to rapamycin. If its effects on fruit flies translate ...

Frying foods, especially using reused oils, creates compounds called advanced glycation end products (AGEs), which activate inflammatory responses. Fast food often combines many of these ...

In the in vitro glycation assay, RuDiOBn inhibited the formation of advanced glycation end products in collagen via the glyoxal pathway, with an IC 50 (μg/mL) equal to 2.45 ± 0.47. In the cytotoxicity ...

The inflammatory pulmonary disease candidate is called ARO-RAGE. It is an RNAi therapeutic targeting the receptor for advanced glycation end-products (RAGE), which is implicated as an upstream ...

The best moisturiser for mature skin is one that works well beyond its job description. As we age, our collagen reserves deplete and skin loses its firmness and elasticity, while fine lines and ...

Department of Biophysics, Molecular Biology and Bioinformatics, University of Calcutta, 92 A.P.C. Road, Kolkata 700009, India ...

However, discrepancies between these two metrics have led to the identification of distinct glycation phenotypes, with potential implications for vascular complications. This study investigates the ...

But the thick, oozy liquid contains high amounts of sugar, which can contribute to glycation. This is when "sugar molecules bind to skin proteins like elastin, making the skin less firm and more ...

The Deep South Resource Center for Minority Aging Research (RCMAR) invites Letters of Intent to apply for one-year pilot grants focusing on minority aging and health equity. While we are interested in ...