We report the efficacy of a new peptide with agonism at the glucagon and GLP-1 receptors that has potent, sustained satiation-inducing and lipolytic effects. Selective chemical modification to ...

However, when obese mice without INSP3R1 were chronically treated with glucagon, the hormone had no effect. “These results provide new insights into glucagon biology and suggest that mitochondrial ...

Many of the projects in the Habegger group investigate novel pharmacological therapies against diabetes and obesity in rodent models. Current projects include 1) the non-cannonical aspects of glucagon ...

The hormone glucagon, secreted by the pancreas, ... "These results provide new insights into glucagon biology and suggest that mitochondrial calcium transport, mediated by INSP3R1, ...

Glucagon, a hormone best known for promoting blood sugar production in the liver, also appears to play a key role in maintaining kidney health. When UT Southwestern Medical Center researchers ...

Glucagon can also play a role in how amino acids (compounds that help make up muscles and tissue in your body) make glucose. And it can break down triglycerides, or fat your body stores, into fuel.

A new study led by Ananda Basu, M.D., used novel non-radioactive, stable glucagon tracers for the first time to characterize glucagon metabolism in humans with and without Type 1 diabetes ...

As for intranasal glucagon (Baqsimi), which was first FDA approved in July 2019, out-of-pocket costs were lower than unmixed glucagon for commercially insured patients. Median costs were $10.89 in ...

UAB Comprehensive Diabetes Center (UCDC) scientist Kirk Habegger, Ph.D., is featured in the Diabetes Spotlight in the May 2025 issue of Diabetes, the flagship research publication of the American ...

"These results provide new insights into glucagon biology and suggest that mitochondrial calcium transport, mediated by INSP3R1, may represent a novel target for therapies that aim to reverse ...