TMC207 inhibits the proton pump of mycobacterial ATP synthase, a critical enzyme in the synthesis of ATP for Mycobacterium tuberculosis. Resistance is achieved through mutations at position 63 or ...

Enzymes, the core catalysts in life, drive critical biological processes ranging from metabolic regulation to energy ...

Determining enzyme mechanisms includes determining their kinetic and thermodynamic properties. Cyclic GMP-AMP synthase (cGAS), an intracellular sensor of dsDNA, is a central driver of inflammatory ...

These findings can help move skin healthcare forward. The Rnf complex is a key respiratory enzyme of anaerobes and nitrogen-fixing bacteria. Here, the authors combine structural, computational ...

Edited by Donald Ort, University of Illinois at Urbana Champaign, Urbana, IL; received December 10, 2024; accepted January 28, 2025 ...

Edited by Wilfred van der Donk, University of Illinois at Urbana-Champaign, Urbana, IL; received November 27, 2024; accepted February 21, 2025 ...