PALO ALTO, CA / ACCESS Newswire / May 30, 2025 / Riboscience, LLC, today announced the presentation of data from the completed dose escalation Phase 1a of the Phase 1a/b clinical trial of the ENPP1 ...

Mutation of Lis1, a key dynein regulator, can lead to the rare mental developmental disorder lissencephaly, or “smooth brain, ...

Our cells rely on microscopic highways and specialized protein vehicles to move everything—from positioning organelles to ...

Both RadA and ComM helicases form hexameric rings and use ATP hydrolysis as an energy source to propel themselves along DNA. In this study, we present the cryoEM structures of RadA and ComM ...

Here, we use single-molecule fluorescence to interrogate the conformational state of SecYEG throughout the ATP hydrolysis cycle of SecA. We show that the SecYEG channel fluctuations between open and ...

Annotated functional motifs include the proposed substrate entry point (FVG); ATP hydrolysis motifs Walker A and B, and the second region of homology (SRH); and the zinc-binding proteolytic site ...

Helicases and topoisomerases are energy-coupling enzymes that convert the energy of ATP hydrolysis into structural changes in their substrates. RNA helicases mediate a multitude of RNA rearrangements ...

Current heart failure therapies unload the failing heart without targeting the underlying problem of reduced cardiac contractility. Traditional inotropes (ie, calcitropes) stimulate contractility via ...

which is referred to as ATP hydrolysis, to block inappropriate immune responses. The researchers performed cell culture experiments and found that E-NTPD8 can hydrolyze ATP added to the cell ...

the team plans to confirm the rotary nature of the molecular motor during ATP hydrolysis. As the architecture of the gliding motor is like ATP synthase, "it is possible the chains share a common ...

39(6), 2260-70 Aregger, R. & Klostermeier, D. (2009) The DEAD-box helicase YxiN maintains a closed conformation during ATP hydrolysis, Biochemistry, 48 (45), 10679-10681 Rudolph, M.G. & Klostermeier, ...

The altered SpoIVA was able to harness the energy released by GTP or ATP hydrolysis to drive a necessary conformational change in the protein but failed to ultimately polymerize specifically in the ...