An exploration of the unanswered questions in how the molecular chaperone Hsp90 supports protein homeostasis, and how single-molecule techniques could drive future breakthroughs in answering them.

To circumvent this potential problem, many cochaperones (for example, p23, Hop, FKBP52, GC-UNC45, Aha1 and others) have probably coevolved not only to modulate Hsp90's ATP hydrolysis activity, but ...

This study presents careful biochemical experiments to understand the relationship between LRRK2 GTP hydrolysis parameters and LRRK2 kinase activity. The authors report that incubation of LRRK2 with ...

Second, lipids uptake, de novo synthesis, and hydrolysis are closely linked with intracellular ... During the process, A series of key enzymes involved in the catalytic reactions, including ATP ...

Zofenopril is a prodrug that, once absorbed, undergoes rapid and complete hydrolysis to the sulfhydryl-containing active metabolite zofenoprilat. In healthy volunteers, a single oral dose of ...

The ATP Next Gen Finals in Jeddah, Saudi Arabia will conclude with Joao Fonseca taking on Learner Tien for the title Sunday December 22. A reminder of the draw: favorite and world No. 20 Arthur ...

Sports Mole provides an in-depth guide to the 2024 Next Gen ATP Finals, including dates, draws, prize money and TV and streaming options. While most of tennis' established stars are now enjoying ...

The Next Gen ATP Finals 2024, which will be held from December 18-22 in Jeddah, Saudi Arabia, will officially bring the season to a close. The tournament is an opportunity for the next generation ...

Top seed Arthur Fils was handed a tough round-robin assignment for next week's Next Gen ATP Finals in Jeddah, as he hopes to complete a run to the title that he fell just short of last year.

The Next Gen ATP Finals is the final stop on the 2024 calendar for elite men's tennis contenders. This is the ultimate opportunity to watch tomorrow's stars today, with players aged 20-and-under ...

Joao Lucas Reis da Silva won the Procopio Cup - a tournament offering lower-ranked Brazilian players a path into the ATP Tour's Rio Open - a week after his Instagram post When Brazilian tennis ...