The team of researchers from Saudi Arabia identified 15 distinct structural states, demonstrating how adenosine triphosphate (ATP) hydrolysis governs DNA translocation and unwinding. This ...

This movement is amplified by ATP hydrolysis into ADP (adenosine diphosphate), which releases an inorganic phosphate. Each ATP binding/hydrolysis/release cycle advances the helicase one "step ...

Kinetic measurements of kinesin-1's front and rear heads reveal how different neck linker orientation regulate their activity, enabling the motor protein to move in a coordinated manner along ...

Scientists at St. Jude Children’s Research Hospital used a series of cryo-EM structures to visualize dynamics pivotal to chromatin remodeling, a process implicated in cancer and developmental ...

The motor domain contains the catalytic site for ATP hydrolysis and the actin or microtubule-binding site. The neck region acts as a lever arm, amplifying the small conformational changes generated by ...