The 49ers are riding a tow game losing streak into Week 17. They are poised to increase it to three in their matchup with the Lions. Here are three reasons why the 49ers will lose to the Lions.

Either way, we’ll likely hear their names often on Monday Night Football, as one of those newcomers will be protecting 49ers’ quarterback Brock Purdy’s blindside against the Lions.

The Detroit Lions and San Francisco 49ers have released their final injury reports of the week ahead of their Monday night showdown in Week 17 and there are a total of six players ruled out and ...

Charvarius Ward will join the list of 49ers missing Monday night’s game against the Lions at Levi’s Stadium after the team ruled him out Sunday afternoon. The veteran cornerback and his ...

Another San Francisco 49ers starting offensive lineman is missing from practice. Starting right tackle Colton McKivitz did not participate in Friday's session. McKivitz was a limited participant ...

Howdy!' A journey down the inked arms — and into the lively mind — of George Kittle I want to buy my 10-year-old nephew a 49ers jersey for Christmas. Which player should I pick so that the ...

The injury report for the Detroit Lions (13-2) heading into their matchup versus the San Francisco 49ers (6-9) has five players. The 49ers (6-9) currently have 15 players listed on this week's ...

At Levi's Stadium on Monday, Amon-Ra St. Brown and the Detroit Lions face George Kittle and the San Francisco 49ers in a matchup between two excellent pass-catchers, starting at 8:15 p.m. ET.

The San Francisco 49ers are prepping for Week 17 against the Detroit Lions on Monday Night Football. What they're not prepping for is a playoff push in January. At 6-9, Kyle Shanahan and the 49ers ...

The San Francisco 49ers suffered a frustrating 29-17 loss to the Miami Dolphins at Hard Rock Stadium, as penalties undermined their chances to secure a critical win in the playoff race.