Up to 59 million from Texas to Michigan are under severe storm risk as heavy rains, flash flooding and strong tornadoes are forecast to hit the lower Ohio Valley and the mid-South.

On the heels of our severe weather late Sunday night, FOX 17 News continues a Code Red Weather Alert for potentially strong to severe thunderstorms Wednesday.

Communities in Middle and West Tennessee are hunkering down as severe weather and inches of rain are expected through the weekend.

A powerful, wide-reaching spring storm is threatening parts of the central and eastern US, with a life-threatening outbreak of long-lived and strong tornadoes possible in some areas. Follow here for live updates.

WATCH: Severe thunderstorm warnings and tornado warnings pepper the Mid-South ahead of main line of extreme weather

Residents of eastern Arkansas, western Tennessee, and western Kentucky prepare for a rare high-risk tornado outbreak as severe storms are forecasted this Wednesday.

A once-in-a generation extreme weather event is beginning Wednesday with a tornado outbreak and will continue into the weekend with dangerous, life-threatening flooding.

Strong, gusty wind is likely all afternoon through tonight. A Wind Advisory remains in effect until 4 am. Expect wind gusts to reach 45 mph at times, potentially knocking out power and blowing down tree limbs or possibly even a few trees.

Forecasters issued some of their rarest and most extreme alerts on Wednesday as they warned a powerful storm system would stall over the central part of the country.