Madness wager between a pro gambler and an artificial-intelligence site will be decided by the winner of the Duke-Houston game in the Final Four.

The Houston Cougars have been to this stage before in recent history. Four years ago, in fact. That team, led by Marcus Sasser and Quentin Grimes, rode a stifling defense to the Final Four, where the inconsistent offense finally came back to bite them in a loss to eventual champs Baylor.

What are Final Four odds now? What to know about Houston Cougars vs Duke Blue Devils point spread, moneyline, over/under for March Madness betting.