The Houston Cougars have been to this stage before in recent history. Four years ago, in fact. That team, led by Marcus Sasser and Quentin Grimes, rode a stifling defense to the Final Four, where the inconsistent offense finally came back to bite them in a loss to eventual champs Baylor.

What are Final Four odds now? What to know about Houston Cougars vs Duke Blue Devils point spread, moneyline, over/under for March Madness betting.