By tethering RNA polymerase with the coupling transcription factor NusG or its paralog or version, RfaH, which threads the ...

With the long-term goal of creating living cells from non-living components, scientists in the field of synthetic biology ...

SAN DIEGO--(BUSINESS WIRE)--TriLink BioTechnologies and Alphazyme, both part of Maravai LifeSciences, have collaborated to launch CleanScribe™ RNA Polymerase, a novel enzyme that reduces double ...

The researchers found that using a drug to inhibit RNA Polymerase 1 (Pol 1) - the enzyme responsible for human ribosomal RNA (rRNA) transcription - triggered a unique stress response that rewires ...

DNA polymerase was isolated in 1956; RNA polymerase, in 1959. Wave Life Sciences, a clinical-stage RNA medicines company, develops A-to-I RNA base editing oligonucleotides (“AIMers”).

Using the RNA origami technique, they succeeded in producing nanotubes that fold into cytoskeleton-like structures. ... To implement the blueprint it contains, RNA polymerase is used.

A breakthrough assay is advancing how researchers observe gene expression in real time. Named QRIVTA (quantitative real-time ...

The RNA polymerase's copying accuracy must exceed a critical threshold to maintain heritable information over multiple generations, ...

A significant percentage of patients with SSc first present with non-RP symptoms — most commonly puffy fingers/hands — and are associated with more severe disease.

More information: James Attwater et al, Trinucleotide substrates under pH–freeze–thaw cycles enable open-ended exponential RNA replication by a polymerase ribozyme, Nature Chemistry (2025 ...