This movement is amplified by ATP hydrolysis into ADP (adenosine diphosphate), which releases an inorganic phosphate. Each ATP binding/hydrolysis/release cycle advances the helicase one "step ...

The team of researchers from Saudi Arabia identified 15 distinct structural states, demonstrating how adenosine triphosphate (ATP) hydrolysis governs DNA translocation and unwinding. This ...

Kinetic measurements of kinesin-1's front and rear heads reveal how different neck linker orientation regulate their activity, enabling the motor protein to move in a coordinated manner along ...

The motor domain contains the catalytic site for ATP hydrolysis and the actin or microtubule-binding site. The neck region acts as a lever arm, amplifying the small conformational changes generated by ...