acts as the motor domain of the molecule and pulls actin filaments along by repetitive conformational changes coupled to ATP hydrolysis. But to understand fully even this fundamental aspect of ...

This movement is amplified by ATP hydrolysis into ADP (adenosine diphosphate), which releases an inorganic phosphate. Each ATP binding/hydrolysis/release cycle advances the helicase one "step ...

The motor domain contains the catalytic site for ATP hydrolysis and the actin or microtubule-binding site. The neck region acts as a lever arm, amplifying the small conformational changes generated by ...

ATP hydrolysis acts like a spring-loaded mechanism, propelling the helicase forward and pulling the DNA strands apart. A key discovery by the KAUST researchers is that two helicases work in tandem ...